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Top 11 Python Frameworks for Web Development

Top 11 Python Frameworks for Web Development

Python isn’t just one of the most beloved programming languages out there—it’s also a powerhouse for web development. Whether you’re launching a startup or scaling an enterprise platform, Python frameworks offer flexible, scalable solutions for building robust web applications efficiently.

But with so many options available, where do you even begin?

We’ve rounded up the 11 best Python frameworks for web development in 2025 — along with why they matter, what they’re good at, and which type of project they’re best suited for.

Django

Django is the go-to framework if you need to build secure, scalable apps fast. Think of it as a batteries-included solution—admin panel, ORM, security, templates—it’s all there, and it’s all Pythonic.

Django

Why we love it:

  • Robust admin interface
  • Built-in authentication and security features
  • Ideal for enterprise-level or content-heavy applications
  • Great for building MVPs and scaling them fast

Great for building MVPs and scaling them fast

Flask

Flask is Django’s minimalist cousin—lightweight, flexible, and ideal for microservices or projects where you want more control over architecture.

Flask

Best for:

  • Small to mid-size web apps
  • APIs and RESTful services
  • Developers who love plug-and-play modularity

If you need a fast MVP or are prototyping ideas with minimal overhead, Flask is a solid pick.

Want a UI for your Flask app? Pair it with our UI/UX Design services to craft something your users will love.

Pyramid

Pyramid is a versatile framework that gives developers the power to choose. You can go minimal like Flask or full-featured like Django.

Pyramid

Key features:

  • Flexible templating engine
  • URL mapping and security baked in
  • Perfect for both simple apps and complex enterprise systems

CherryPy

CherryPy is a microframework that acts like a full-stack solution. It follows object-oriented principles and makes your Python code feel… well, like Python.

CherryPy

Perfect if you want:

  • A small footprint framework for RESTful services
  • Fast performance with minimal overhead
  • A framework that’s easy to learn and deploy

Bottle

If you’re working on something tiny but mighty, Bottle might be your best bet.

Bottle

It’s a single-file framework that works great for:

  • IoT apps
  • Prototyping
  • Educational projects
  • APIs that don’t need all the bells and whistles

Tornado

Tornado shines when you need to handle thousands of open connections—like chat apps, real-time dashboards, or live feeds.

Tornado

Why devs love it:

  • Asynchronous networking
  • High performance under load
  • Great for WebSockets and long-polling

Working on something real-time? Pair it with our Cloud Operations services to ensure scalability.

TurboGears

TurboGears hits the sweet spot between full-featured and flexible.

What makes it special:

  • MVC architecture
  • Reusable components
  • ORM support with SQLAlchemy

Great for developers who want a Django-like experience without the rigid structure.

Web2py

Web2py is an open-source framework known for its ease of use and security-first design.

Web2py

Highlights:

  • Web-based IDE included
  • Simple deployment
  • Built-in ticketing system for error handling

It’s beginner-friendly and still powerful enough for professional-grade apps.

Falcon

Falcon is for building super-fast APIs. It’s minimal, lightweight, and lets you get down to business—no fluff.

Falcon

Great for:

  • Microservices
  • High-performance backend systems
  • JSON-based APIs and mobile app backends

CubicWeb

CubicWeb is a semantic web framework perfect for data-driven apps.

CubicWeb

Why it’s unique:

  • Comes with an ORM and templating engine
  • Great for knowledge-based apps and research platforms
  • Built-in validation and authentication

BlueBream

Formerly known as Zope 3, BlueBream is a component architecture framework with a focus on large-scale systems.

BlueBream

It’s a bit niche, but ideal for:

  • Government or enterprise projects
  • Highly modular applications
  • Developers who need something highly customizable

Conclusion

Choosing the right Python framework can make your web app smoother to build, easier to maintain, and ready to scale. Whether you’re building an MVP, developing a SaaS product, or building enterprise software, there’s a Python framework that fits.

At Plego Technologies, we help startups and enterprises build powerful apps using Python and other modern frameworks. From back-end development to cloud migration and AI integration, we’ve got you covered.