Top 11 Python Frameworks for Web Development
Python isn’t just one of the most beloved programming languages out there—it’s also a powerhouse for web development. Whether you’re launching a startup or scaling an enterprise platform, Python frameworks offer flexible, scalable solutions for building robust web applications efficiently.
But with so many options available, where do you even begin?
We’ve rounded up the 11 best Python frameworks for web development in 2025 — along with why they matter, what they’re good at, and which type of project they’re best suited for.
Table of Contents
Django
Django is the go-to framework if you need to build secure, scalable apps fast. Think of it as a batteries-included solution—admin panel, ORM, security, templates—it’s all there, and it’s all Pythonic.
Why we love it:
- Robust admin interface
- Built-in authentication and security features
- Ideal for enterprise-level or content-heavy applications
- Great for building MVPs and scaling them fast
Great for building MVPs and scaling them fast
Flask
Flask is Django’s minimalist cousin—lightweight, flexible, and ideal for microservices or projects where you want more control over architecture.

Best for:
- Small to mid-size web apps
- APIs and RESTful services
- Developers who love plug-and-play modularity
If you need a fast MVP or are prototyping ideas with minimal overhead, Flask is a solid pick.
Want a UI for your Flask app? Pair it with our UI/UX Design services to craft something your users will love.
Pyramid
Pyramid is a versatile framework that gives developers the power to choose. You can go minimal like Flask or full-featured like Django.
Key features:
- Flexible templating engine
- URL mapping and security baked in
- Perfect for both simple apps and complex enterprise systems
CherryPy
CherryPy is a microframework that acts like a full-stack solution. It follows object-oriented principles and makes your Python code feel… well, like Python.
Perfect if you want:
- A small footprint framework for RESTful services
- Fast performance with minimal overhead
- A framework that’s easy to learn and deploy
Bottle
If you’re working on something tiny but mighty, Bottle might be your best bet.
It’s a single-file framework that works great for:
- IoT apps
- Prototyping
- Educational projects
- APIs that don’t need all the bells and whistles
Tornado
Tornado shines when you need to handle thousands of open connections—like chat apps, real-time dashboards, or live feeds.
Why devs love it:
- Asynchronous networking
- High performance under load
- Great for WebSockets and long-polling
Working on something real-time? Pair it with our Cloud Operations services to ensure scalability.
TurboGears
TurboGears hits the sweet spot between full-featured and flexible.
What makes it special:
- MVC architecture
- Reusable components
- ORM support with SQLAlchemy
Great for developers who want a Django-like experience without the rigid structure.
Web2py
Web2py is an open-source framework known for its ease of use and security-first design.
Highlights:
- Web-based IDE included
- Simple deployment
- Built-in ticketing system for error handling
It’s beginner-friendly and still powerful enough for professional-grade apps.
Falcon
Falcon is for building super-fast APIs. It’s minimal, lightweight, and lets you get down to business—no fluff.
Great for:
- Microservices
- High-performance backend systems
- JSON-based APIs and mobile app backends
CubicWeb
CubicWeb is a semantic web framework perfect for data-driven apps.
Why it’s unique:
- Comes with an ORM and templating engine
- Great for knowledge-based apps and research platforms
- Built-in validation and authentication
BlueBream
Formerly known as Zope 3, BlueBream is a component architecture framework with a focus on large-scale systems.
It’s a bit niche, but ideal for:
- Government or enterprise projects
- Highly modular applications
- Developers who need something highly customizable
Conclusion
Choosing the right Python framework can make your web app smoother to build, easier to maintain, and ready to scale. Whether you’re building an MVP, developing a SaaS product, or building enterprise software, there’s a Python framework that fits.
At Plego Technologies, we help startups and enterprises build powerful apps using Python and other modern frameworks. From back-end development to cloud migration and AI integration, we’ve got you covered.